Vincenzo Fodale, MD

Aggregated Professor Anesthesia Intensive Care

Dpt. of Neurosciences, Section of Anesthesiology

University of Messina, Italy

Anesthetics and Alzheimer's Disease

Guest Editors:

  P.K.MANDAL & V. FODALE

Journal of Alzheimer's Disease

 2010;22 Suppl 3:35-41

 

Simulation in OR

Deep Brain Stimulation (DBS)

Neuroradiology

Neurosurgery

 
 
 
 
 
 
 
Home Researches & Grants Consulting Pain Therapy Congresses Infoanesthesia.com
 
Contact Information:

 

University of Messina

Dpt. of di Neuroscience - Section of Anestesiology

 

U.O.S. Dipartimentale di Anestesia e Scienze Neurointensive

Azienda Ospedaliera Universitaria Policlinico G.Martino

Via C. Valeria 1, Pad. E

98125 Messina 

Tel: + 39 090 221 2817    

E-mail: vfodale@unime.it

 

WEBSITES:     

www.fodale.it        (Italian)

www.fodale.com   (English)

 

UNIVERSITY OF MESSINA FACULTY WEBSITE

 

RESEARCH WEBSITES 

http://www.infoanestesia.it/         (Italian)

http://www.infoanesthesia.com/  (English)

 

Research websites supported from a grant from the Italian Ministry for University and Research, Program for the Development of Research of National Interest (PRIN Grant No.2007H84XNH - Scientific coordinator: V. Fodale)

 

Advanced Medical Simulation in Anesthesia Intensive Care & Emergency

 
 

Researches:

  • Neuroscience

  • Anesthesia &  Alzheimer's Disease

  • Postoperative Cognitive Dysfunction (POCD)

  • Neuroprotection

  • Opioids

  • Brain Monitoring in Anesthesia e Intensive Care

 Other:

  • Certificated European Society of Regional Anesthesia (ESRA)

  • Associate Editor 2009,2011 "Journal of Alzheimer's Disease"

  • Reviewer "Critical Care Medicine", "Anesthesiology", "British Journal Anaesthesia"

  • Referee "Acta Anaesthesiologica Scandinavica"

     

INFOANESTHESIA.com

Several commonly used inhaled anaesthetics could be involved in neurotoxicity and neuro-degeneration. It has alerted anesthesiologists, neuropsychologists, surgeons and other clinicians to initiate in-depth clinical research on the potential role of anesthetics in neuro-toxicity.The website does not intend to engender a ‘fear of anesthesia’ that could lead to irrational rejection of surgery, but to provide a platform to bring the latest scientific studies to research and clinical communities, and to encourage the earnest quest for the ‘safe anesthetic’ and advancement of the current scientific knowledge in this area (Link to INFOANESTHESIA.COM).

 
 
 
 
 
 
 
 
 
 
 
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LIST OF SCIENTIFIC PUBLICATIONS

 
       
Articles in Journals Indexed in PUBMED  [Impact Factor by Journal Citation Reports, 2011]
 

Click here to update the PubMed List

     

 

Papers

Impact Factor

1

Fodale V, D'Arrigo MG, Grasso G. Intestinal ischemia/reperfusion promotes brain damage via microglia activation: Can we do something now?

Crit Care Med. 2012 Aug;40(8):2523-4.

6.254

2

La Monaca E, Fodale V. Effects of Anesthetics on Mitochondrial Signaling and Function.

Curr Drug Saf. 2012;7(2):126-39.

 

3

Giovanni Grasso G, Certo F, Pirrone AG, Fodale V, Giambartino F. Vascular and pulmonary embolisms following percutaneous vertebroplasty : Case report and review of the literature.

J Neurosurg Spine (In Press)

1.534
4

Schifilliti D, Mondello S, D'Arrigo MG, Chillè G, Fodale V. Genotoxic effects of anesthetic agents: an update.

Expert Opin Drug Saf. 2011 Nov;10(6):891-9.

3.015

5

Schifilliti D, Grasso G, Conti A, Fodale V. Anaesthetic-related neuroprotection: intravenous or inhalational agents?

CNS Drugs. 2010 Nov;24(11):893-907.

4.795

6

Fodale V, Ritchie K, Rasmussen LS, Mandal PK. Anesthetics and Alzheimer's disease: background and research. Preface.

J Alzheimers Dis. 2010;22 Suppl 3:1-3.

3.745

7

Bilotta F, Doronzio A, Stazi E, Titi L, Fodale V, Di Nino G, Rosa G. Postoperative cognitive dysfunction: toward the Alzheimer's disease pathomechanism hypothesis.

J Alzheimers Dis. 2010;22 Suppl 3:81-9.

3.745

8

Mandal PK, Fodale V. Anesthetics and Alzheimer's disease.

J Alzheimers Dis. 2010;22 Suppl 3:135-6.

3.745

9

Di Nino G, Adversi M, Dekel BG, Fodale V, Rosa G, Melotti RM. Peri-operative risk management in patients with Alzheimer's disease.

J Alzheimers Dis. 2010;22 Suppl 3:121-7.

3.745

10

Schifilliti D, Santamaria LB, Rosa G, Di Nino G, Mandal PK, Fodale V. Cholinergic central system, Alzheimer's disease, and anesthetics liaison: a vicious circle?

J Alzheimers Dis. 2010;22 Suppl 3:35-41.

3.745

11

Mandal PK, Simplaceanu V, Fodale V. Intravenous anesthetic diazepam does not induce amyloid-beta peptide oligomerization but diazepam co-administered with halothane oligomerizes amyloid-beta peptide: an NMR study.

J Alzheimers Dis. 2010;20(1):127-34.

3.745

12

Fodale V, Santamaria LB, Schifilliti D, Mandal PK. Anaesthetics and postoperative cognitive dysfunction: a pathological mechanism mimicking Alzheimer's disease.

Anaesthesia. 2010 Apr;65(4):388-95.

2.958

13

Mandal PK, Bhavesh NS, Chauhan VS, Fodale V. NMR investigations of amyloid-β peptide interactions with propofol at clinically relevant concentrations with and without aqueous halothane solution.

J Alzheimers Dis. 2010;21(4):1303-9.

3.745

14

Mandal PK, Fodale V. In reply to: Can a call for prudence be simply alarmist?

Eur J Anaesthesiol. 2010 Mar;27(3):309-11.

1.679

15

Mandal PK, Fodale V. Smaller molecular-sized anaesthetics oligomerize Abeta peptide simulating Alzheimer's disease: a relevant issue.

Eur J Anaesthesiol. 2009 Oct;26(10):805-6.

1.679

16

Santamaria LB, Schifilliti D, La Torre D, Fodale V. Drugs of anaesthesia and cancer.

Surg Oncol. 2010 Jun;19(2):63-81.

2.444

17

Mandal PK, Schifilliti D, Mafrica F, Fodale V. Inhaled anesthesia and cognitive performance.

Drugs Today (Barc). 2009 Jan;45(1):47-54.

1.59

18

Mandal PK, Fodale V. Isoflurane and desflurane at clinically relevant concentrations induce amyloid beta-peptide oligomerization: an NMR study.

Biochem Biophys Res Commun. 2009 Feb 13;379(3):716-20.  

2.484

19

Fodale V, Mondello S, Aloisi C, Schifilliti D, Santamaria L. Genotoxic effects of anesthetic agents.

Expert Opin Drug Saf. 2008 Jul;7(4):447-58.

3.015

20

Mafrica F, Fodale V. Thyroid function, Alzheimer's disease and postoperative cognitive dysfunction: a tale of dangerous liaisons?

J Alzheimers Dis. 2008 May;14(1):95-105.

3.745

21

Fodale V, Mafrica F, Santamaria LB, Coleman JJ. Killer fentanyl: is the fear justified?

Expert Opin Drug Saf. 2008 May;7(3):213-7.

3.015

22

Fodale V, La Monaca E. Propofol infusion syndrome: an overview of a perplexing disease. Drug Saf. 2008;31(4):293-303.

3.634

23

Fodale V, Schifilliti D, Pratic̣ C, Santamaria LB. Remifentanil and the brain.

Acta Anaesthesiol Scand. 2008 Mar;52(3):319-26.

2.188

24

Mondello S, Fodale V, Cannaṿ S, Aloisi C, Almoto B, Buemi M, Santamaria LB. Hypophosphatemia as unusual cause of ARDS in Cushing's syndrome secondary to ectopic CRH production. A case report.

ScientificWorldJournal. 2008 Feb 6;8:138-44.

1.524

25

Fodale V, Santamaria LB, Grasso G. Neuroprotective properties of xenon and helium in an in vitro model of traumatic brain injury: one small step or one big jump?

Crit Care Med. 2008 Feb;36(2):647-8.

6.254

26

Fodale V, Santamaria LB. Cholinesterase inhibitors improve survival in experimental sepsis: a new way to activate the cholinergic anti-inflammatory pathway.

Crit Care Med. 2008 Feb;36(2):622-3.

6.254

27

Grasso G, Meli F, Fodale V, Calapai G, Buemi M, Iacopino DG. Neuroprotective potential of erythropoietin and darbepoetin alfa in an experimental model of sciatic nerve injury. Laboratory investigation.

J Neurosurg Spine. 2007 Dec;7(6):645-51.

1.534

28

Fodale V, Romeo M, Mafrica F. Fentanyl are we paying too high a price?

J Opioid Manag. 2007 May-Jun;3(3):123-6.

 

29

Grasso G, Sfacteria A, Meli F, Fodale V, Buemi M, Iacopino DG. Neuroprotection by erythropoietin administration after experimental traumatic brain injury.

Brain Res. 2007 Nov 28;1182:99-105.

2.728

30

Grasso G, Sfacteria A, Meli F, Passalacqua M, Fodale V, Buemi M, Giambartino F, Iacopino DG, Tomasello F. The role of erythropoietin in neuroprotection: therapeutic perspectives.

Drug News Perspect. 2007 Jun;20(5):315-20.

2.208

31

Fodale V, Schifilliti D, Conti A, Lucanto T, Pino G, Santamaria LB. Transcranial Doppler and anesthetics.

Acta Anaesthesiol Scand. 2007 Aug;51(7):839-47.

2.188

32

Santamaria LB, Di Paola C, Mafrica F, Fodale V. Preanesthetic evaluation and assessment of children with Down's syndrome.

ScientificWorldJournal. 2007;7:242-51.

1.524

33

Fodale V. In reply: Alzheimer's disease and anaesthesia.

Br. J. Anaesth. (2007) 98 (5): 692-694.

4.243

34

Mafrica F, Fodale V. Down subjects and Oriental population share several specific attitudes and characteristics. Med Hypotheses. 2007;69(2):438-40.

1.150

35

Mafrica F, Fodale V. Opioids and Down's syndrome.

J Opioid Manag. 2006 Mar-Apr;2(2):93-8.

 

36

Fodale V, Di Pietro R, Santamaria S. Viagra, surgery and anesthesia: a dangerous cocktail with a risk of blindness.

Med Hypotheses. 2007;68(4):880-2.

1.150

37

Fodale V, Mafrica F, Santamaria LB. Killer fentanyl: a lesson from anaesthesiology. Lancet. 2006 Oct 7;368(9543):1237-8.

38.28

38

Fodale V, Quattrone D, Trecroci C, Caminiti V, Santamaria LB. Alzheimer's disease and anaesthesia: implications for the central cholinergic system.

Br J Anaesth. 2006 Oct;97(4):445-52.

4.243

39

Fodale V, Mafrica F, Caminiti V, Grasso G. The cholinergic system in Down's syndrome.

J Intellect Disabil. 2006 Sep;10(3):261-74.

 

40

Fodale V, Di Pietro R, Ferreri F, Tescione M, Russo G, Santamaria S, Pratic̣ C. The effect of peribulbar block with ropivacaine on bi-hemispheric cerebral oxygen saturation in aged patients.

Anaesthesia. 2006 Aug;61(8):764-7.

2.958

41

Conti A, Iacopino DG, Fodale V, Micalizzi S, Penna O, Santamaria LB. Cerebral haemodynamic changes during propofol-remifentanil or sevoflurane anaesthesia: transcranial Doppler study under bispectral index monitoring.

Br J Anaesth. 2006 Sep;97(3):333-9.

4.243

42

Fodale V, Pratico C, Tescione M, Tanania S, Lucanto T, Santamaria LB. Evidence of acute tolerance to remifentanil in intensive care but not in anesthesia.

 J Clin Anesth. 2006 Jun;18(4):293-6.

1.213

43

Fodale V, Tescione M, Roscitano C, Pino G, Amato A, Santamaria LB. Effect of tramadol on Bispectral Index during intravenous anaesthesia with propofol and remifentanil.

Anaesth Intensive Care. 2006 Feb;34(1):36-9.

1.128

44

Mafrica F, Schifilliti D, Fodale V. Pain in Down's syndrome. ScientificWorldJournal. 2006 Jan 26;6:140-7.

1.524

45

Fodale V, Pratic̣ C, Signer MR, Santamaria LB. Perinatal neuroprotection by muscle relaxants against hypoxic-ischemic lesions: is it a possible hypothesis?

J Matern Fetal Neonatal Med. 2005 Aug;18(2):133-6.

1.495

46

Pratic̣ C, Quattrone D, Lucanto T, Amato A, Penna O, Roscitano C, Fodale V. Drugs of anesthesia acting on central cholinergic system may cause post-operative cognitive dysfunction and delirium.

Med Hypotheses. 2005;65(5):972-82.

1.150

47

Fodale V, Mazzeo A, Pratic̣ C, Aguennouz M, Toscano A, Santamaria LB, Vita G. Fatal exacerbation of peripheral neuropathy during lamivudine therapy: evidence for iatrogenic mitochondrial damage.

Anaesthesia. 2005 lug;60(8):806-10.

2.958

48

Fodale V, Praticó C, Tescione M, Lucanto T, Tanania S, Santamaria LB. Comparative cost-analysis of a propofol-cisatracurium-based anesthesia with remifentanil or fentanyl for laparoscopic surgery.

 Surg Laparosc Endosc Percutan Tech. 2005 Jun;15(3):149-52.

1.227

49

Fodale V, Pratic̣ C, Tescione M, Tanania S, Lucanto T, Santamaria LB. Tramadol does not modify the Bispectral Index during anaesthesia with sevoflurano and remifentanil.

Br J Anaesth. 2005 Aug;95(2):212-5.

4.243

50

Fodale V, Pratic̣ C, Lucanto T, Mazzeo AT, Pino G, Santamaria LB. Complete recovery from prolonged cardiac arrest following self-administration of cisatracurium.

Eur J Anaesthesiol. 2005 Jan;22(1):73-5.

1.679

51

Pratic̣ C, Fodale V, D’Amico AM, Lamberto S, Santamaria LB. Prolonged Placement of the new temporary Montanari’s vena cava filter.

Clin Intensive Care 2005 Mar; 16(1):43-5.

 

52

Fodale V, Santamaria LB. In clinical practice, coadministration of sevoflurane or propofol could antagonize remifentanil stimulation of N-methyl-D-aspartate receptors.

Anesthesiology. 2005 Mar;102(3):695-6.

5.359

53

Fodale V, Pratic̣ C, Leto G, Caminiti V, Mazzeo AT, Lucanto T. In Reply : Propofol relieves post-extubation laryngospasm in obstetric anesthesia.

Int J Obstet Anesth. 2005 Jan;14(1): 80-81.

1.395

54

Fodale V, Mondello B, Mirenda F, Spinelli F, Santamaria LB. Tramadol and vocal cord closure.

Anesthesiology. 2005 Jan;102(1):227-9.

5.359

55

Fodale V, Pratico C. Bispectral Index monitoring for assessment of level of consciousness in brain-injured patients: the journey continues.

Crit Care Med. 2004 Dec;32(12):2545-6.

6.254

56

Fodale V, Tescione M, Pratic̣ C. Cholinesterase inhibitors, neuromuscular blocking drugs and perioperative memory enhancement.

Anesthesiology. 2004 Dec;101(6):1483-4.

5.359

57

Barbuscia M, Gorgone S, Di Pietro N, Rizzo AG, Melita G, Fodale V, Saṇ M, De Luca M, Marando A, Pratic̣ C. Ileum-colon junction benign obstructions.

G Chir. 2004 Jun-Jul;25(6-7):251-8.

 

58

Fodale V, Pratic̣ C, Santamaria LB. Coadministration of propofol and midazolam decreases bispectral index value as a result of synergic muscle relaxant action on the motor system.

Anesthesiology. 2004 Sep;101(3):799.

5.359

59

Fodale V, Pratic̣ C, Leto G, Caminiti V, Mazzeo AT, Lucanto T. Propofol relieves post-extubation laryngospasm in obstetric anesthesia.

Int J Obstet Anesth. 2004 Jul;13(3):196-7.

1.395

60

Fodale V, Santamaria LB. Different actions of sevoflurane and propofol on central nicotinic receptors may explain differences in hypnotic antagonism by cholinesterase inhibitors.

Br J Anaesth. 2004 May;92(5):773-4.

4.243

61

Fodale V, Pratic̣ C, Santamaria LB. Potential neuroprotective properties of atracurium and cisatracurium in neurosurgical anaesthesia.

Eur J Anaesthesiol. 2004 Apr;21(4):333-5.  

1.679

62

Fodale V, Santamaria LB. Is overestimation of bispectral index in sedated intensive care unit patients only related to electromyographic activity?

Anesthesiology. 2004 Mar;100(3):746-7.

5.359

63

Fodale V, Pratic̣ C, Santamaria LB. Drugs of anesthesia, central nicotinic receptors and Parkinson's disease.

Parkinsonism Relat Disord. 2004 Mar;10(3):189-90.

3.795

64

Fodale V, Pratic̣ C, Girlanda P, Baradello A, Lucanto T, Rodolico C, Nicolosi C, Rovere V, Santamaria LB, Dattola R. Acute motor axonal polyneuropathy after a cisatracurium infusion and concomitant corticosteroid therapy.

Br J Anaesth. 2004 Feb;92(2):289-93.

4.243

65

Fodale V, Pratico' C, Piana F, Caruso A, Lucanto T, Coniglio S, Santamaria LB. Propofol and remifentanil without muscle relaxants in a patient with myasthenia gravis for emergency surgery.

Can J Anaesth. 2003 Dec;50(10):1083-4.

2.346

66

Fodale V, Santamaria LB. The inhibition of central nicotinic nAch receptors is the possible cause of prolonged cognitive impairment after anesthesia.

Anesth Analg. 2003 Oct;97(4):1207.

3.286

67

Fodale V, Santamaria LB. Drugs of anesthesia, central nicotinic receptors and post-operative cognitive dysfunction.

Acta Anaesthesiol Scand. 2003 Oct;47(9):1180-1.

2.188

68

Barbuscia M, Pratic̣ C, Rizzo AG, Puliatti F, Melita G, Fodale V, Mazzeo AT, Gorgone S. Treatment of substernal goiter. Our experience.

G Chir. 2003 May;24(5):193-7.

 

69

Fodale V, Santamaria LB. The possible neuroprotective effect of laudanosine, an atracurium and cisatracurium metabolite.

Acta Anaesthesiol Scand. 2003 Jul;47(6):780; 780-1.

2.188

70

Fodale V, Santamaria LB. Laudanosine, an atracurium and cisatracurium metabolite.

Eur J Anaesthesiol. 2002 Jul;19(7):466-73.

1.679

 
 
       
BOOK CHAPTERS
 
Fodale V. Drug interactions in anaesthetic practice. In: Gullo A. (Ed.), Anaesthesia, Pain, Intensive Care and Emergency Medicine. Springer-Verlag, Milano 2006, pp.585-94. ISBN 978-88-470-0406-1  DOI: 10.1007/88-470-0407-1_50

Fodale V, Di Pietro R, Rovella D, Fortunato M. Surgery anesthesia and blindness. In:: Jeffrey Higgins and Dominique Truax (Editors) “ Blindness and Low Vision”. Chapter 5.Nova Science Publishers, 2009, pp. 151-164.  ISBN: 978-1-60692-630-7